The overexpression of arginase‐2 (Arg2) (a regulatory protein of inflammatory mediators), cytochrome P4502E1 (Cyp2e1) (one of the oxidative stress indicators), serum amyloid A3 (Saa3) (a pro‐inflammatory cytokine), serpina3n (an acute‐phase inflammatory protein), and haptoglobin (an acute‐phase antibacterial protein) in mice with DSS‐induced colitis were significantly reduced after 2′‐FL administration. The gene discussed is ARG2; the disease is colitis.