Previous studies have also found that serpina3n, an inhibitor of NE release from T lymphocytes, is not only increased in serum and fecal expression of serpina3n in IBD patients, but also highly expressed in DSS‐induced colitis animals as well as in Citrobacter rodentium‐stimulated IEC cells, which was associated with the inhibitory effects of serpina3n on tissue damage induced by extracellular neutrophil elastase (Barry et al. 2020; Ho et al. 2021). The gene discussed is ELANE; the disease is colitis.