The overexpression of intestinal CYP2E1 contributes to the disruption of barrier integrity and epithelial hyper‐permeability, partly due to the ROS‐releasing mechanism (Makaro et al. 2025; Mun et al. 2024) In this study, the abnormally elevated protein level of Cyp2e1, which was consistent with the clinical findings that the immunohistochemical expressions of Cyp2e1 in the enterocytes of colon tissues from patients with Crohn's disease or ulcerative colitis were elevated, compared to the controls (Plewka et al. 2014). This evidence concerns the gene CYP2E1 and ulcerative colitis.