CDKN1A and osteoarthritis: Along similar lines, the downregulation of miR-29b-5p in chondrocytes and articular cartilage with age has been associated with osteoarthritis and biologically to the upregulation of senescence markers (p16ink4a and p21cip1/waf1) as well as matrix metalloproteinases, which have an established role in osteoarthritis pathogenesis [153].