There was a significantly higher risk of developing a dementia diagnosis in Hispanic/Latino and NHB participants than NHW participants and comparably increased dementia hazard ratios in the Hispanic/Latino, NHB, and NHW APOE4 carriers than non‐carriers (hazard ratio [HR] [95% confidence interval {CI}] 1.54 [1.25–1.91], 1.25 [1.00–1.57], and 1.55 [1.40–1.72]). This evidence concerns the gene APOE and dementia.