Analysis in the 14,937 NHB individuals showed that the combined APOE4 carrier group had a significant increased risk for having a dementia diagnosis while the individual NHB APOE4 heterozygote and homozygote groups showed a non‐significant trend toward increased risk compared to the NHB non‐carrier reference group (APOE4 carriers: HR 1.25, 95% CI 1.00–1.57, p = 0.04; heterozygote: HR 1.22, 95% CI 0.97–1.54, p = 0.09; homozygote: HR 1.52, 95% CI 0.91–2.53, p = 0.10, Figure 1A and Table S1). Here, APOE is linked to dementia.