PDGFRB and neoplasm: In CRC, the PDGF signaling pathway significantly contributes to tumor growth, invasion, angiogenesis, and metastasis by stimulating various downstream signaling cascades, primarily through the overproduction of PDGF ligands and their receptors (PDGFRs), particularly PDGFR-β, which results in increased cell proliferation, migration, and survival [78, 79].