Bossart et al. demonstrated that Macaca fascicularis with diet-induced obesity treated with the GLP-1/GIP/GCGR triagonist SAR441255 for 42 days experienced a significant body weight reduction of 12.6% ± 1.74% compared to controls (p < 0.05). The gene discussed is GIP; the disease is obesity due to melanocortin 4 receptor deficiency.