Similarly, 5-HETE ((6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid) a product of 5-lipoxygenase (5-LOX), has been associated with immune evasion in cholangiocarcinoma [60], distinguishes HBV-associated HCC from non-viral HCC and shows enhanced diagnostic accuracy when combined with arachidonic acid (AUC = 0.93 vs. 0.76 for AFP) [61]. This evidence concerns the gene ALOX5 and cholangiocarcinoma.