PPARA and hepatocellular carcinoma: KEGG pathway enrichment analysis indicated that the DEGs were significantly enriched in multiple metabolic and signaling pathways, including primary bile acid biosynthesis, fatty acid degradation, linoleic acid metabolism, hormone biosynthesis, fatty acid metabolism, biosynthesis of unsaturated fatty acids, alpha-Linolenic acid metabolism, Enter lipid metabolism, Steroid hormone biosynthesis and PPAR signaling pathway (Fig. 2F, Table S4), These findings suggest that lipid metabolism-related pathways play a key role in the occurrence and progression of HCC.