ONECUT2 and neoplasm: The developmental transcription factor ONECUT2 (One cut domain family member 2; OC2) has been associated with tumor cell proliferation, epithelial-mesenchymal transition (EMT) and metastasis in several cancer types (Ma et al. 2022; Sunita Prajapati et al. 2024; Zamora et al. 2025; Rotinen et al. 2018).