While YAP1 was initially proposed as a defining transcription factor of a distinct SCLC molecular subtype, recent studies have reclassified the YAP1-expressing subtype as non-SCLC (Ng et al. 2024), and evidence suggests that YAP1 is not a subtype-specific transcription factor in SCLC tumors (Baine et al. 2020). The gene discussed is YAP1; the disease is small cell lung carcinoma.