ONECUT2 and small cell lung carcinoma: Consistently, OC2 immunostaining of a SCLC TMA that includes non-tumor lung tissue and malignant small cell lung carcinoma, revealed that OC2 is highly expressed in the nucleus and cytoplasm of tumor cells, while non-tumor tissues showed low or no expression of OC2 (Fig. 1B, C and Supplementary Fig. 1C).