However, in hepatocytes, bavachin can induce ER stress through AMPK/mTORC1 signaling (Yang, et al. 2021)Therefore, in addition to this study suggesting that bavachin regulates mitochondrial β-oxidation through MFN2-dependent mechanism, whether bavachin protects AKI by regulating mitochondrial metabolic network, especially the above molecules, remains to be further proved in the future. Here, MFN2 is linked to acute kidney injury.