The deficiency of Mfn1 and Mfn2 led to abnormal mitochondrial morphology and lipid metabolism disorder in AEC2 cells, with a significant decrease in cholesterol and specific glycerophospholipids, affecting the normal synthesis of pulmonary surfactants, thereby promoting the progression of pulmonary fibrosis (Chung, et al. 2019). This evidence concerns the gene MFN2 and pulmonary fibrosis.