Notably, a recent research indicated that MFN2 not only inhibits mitochondrial fragmentation, proliferation, migration, and invasion in clear cell renal cell carcinoma (ccRCC) cells and xenograft tumor growth but also suppresses disease progression and improves prognosis in ccRCC patients by blocking cellular lipid metabolism and reducing lipid droplet accumulation (Cai, et al. 2024). This evidence concerns the gene MFN2 and clear cell renal carcinoma.