Notably, a recent research indicated that MFN2 not only inhibits mitochondrial fragmentation, proliferation, migration, and invasion in clear cell renal cell carcinoma (ccRCC) cells and xenograft tumor growth but also suppresses disease progression and improves prognosis in ccRCC patients by blocking cellular lipid metabolism and reducing lipid droplet accumulation (Cai, et al. 2024). Here, MFN2 is linked to nonpapillary renal cell carcinoma.