After confirming the secretory nature of the cells through PAX8 expression, proteomic analysis of the hPFTSECs revealed alteration in pathways and candidate proteins associated with various processes such as estrogen signaling, ovulation, embryo development, implantation, pregnancy complications, ectopic pregnancies, sperm functions, apoptosis, senescence, cell cycle regulation, DNA damage, ovarian cancers, etc. The proteomic results were validated by confirming the expression of two significantly more abundant proteins, Kininogen-1 and Annexin-V, in hPFTSECs treated with 5 and 10 μM CC. This evidence concerns the gene ANXA5 and ovarian carcinoma.