Cdh1 loss is often linked to enhanced β-catenin signalling, reflected here by increased promoter activation of β-catenin targets such as Apcdd1, Axin2, Nkd1, Notum and Sp5—primarily in ∆Ecad female melanomas—with corresponding gene expression (Extended Data Fig. 6a–j). The gene discussed is CDH1; the disease is melanoma.