SP140 and infection: Consistent with this observation and the role of RESIST as a critical driver of IFN-I in Sp140−/− BMMs, Sp140−/−Resist1−/−Resist2−/− BMMs were more susceptible to MHV68-GFP infection than Sp140−/− BMMs, and phenocopied the susceptibility of Sp140−/−Ifnar−/− BMMs (Fig. 5e).