These findings suggest that HK2 mitochondria localization and enzymatic activity directly impedes microglial phagocytosis, consistent with our finding that microglia exposed to HF display increased synthesis of fructose 6-phosphate from fructose and increased mitochondrial localization concomitant with decreased phagocytosis capacity which could be reversed by inhibiting HK2 activity. Here, HK2 is linked to hydrops fetalis.