No significant changes were observed at week 12 in enhanced liver fibrosis (ELF) score (including procollagen 3 N-terminal propeptide, tissue inhibitor of metalloproteinase 1 and hyaluronic acid), released N-terminal propeptide of type III collagen (PRO-C3), cytokeratin 18 (CK-18) fragment M30 or CK-18 fragment M65, in any treatment group. Here, TIMP1 is linked to Hepatic fibrosis.