IFITM5 and osteogenesis imperfecta type 5: The other two cases were OI type 5, IFITM5-related, (OMIM#610967), observed in fetus 20 with severe angular deformity of the femurs, lower legs, and forearms (Fig. 2A) and a molecularly unsolved gracile bone dysplasia seen in fetus 29 (Fig. 2F), which is discussed further below.