REST and viral infectious disease: Interestingly, these are part of pathways activated by signaling: STAT1 by viral infections inducing the cellular anti-viral defense, Rcor1 as part of a complex recruited by REST following injury in primary sensory neurons that may contribute to hyperexcitability56, Fosl2/Jun activation by an axonal injury that promotes axonal regeneration57 and Nfe2l1 that translocate to nucleus upon cellular stress and induces genes necessary for stress adaptation58.