Interestingly, these are part of pathways activated by signaling: STAT1 by viral infections inducing the cellular anti-viral defense, Rcor1 as part of a complex recruited by REST following injury in primary sensory neurons that may contribute to hyperexcitability56, Fosl2/Jun activation by an axonal injury that promotes axonal regeneration57 and Nfe2l1 that translocate to nucleus upon cellular stress and induces genes necessary for stress adaptation58. The gene discussed is FOSL2; the disease is viral infectious disease.