Interestingly, while many KMT2C and MT-ND5 mutations were noted in HNSCC or CESC, no mutations were noted at KMT2C N729D or MT-ND5 c.891-892 or c.1278-1279 as seen in HPV-associated SNSCC (Supplementary Figs. 4A–D). Here, MT-ND5 is linked to cervical squamous cell carcinoma.