KDM1A and rheumatoid arthritis: Epigenetic alterations, such as DNA methylation and histone acetylation, play crucial roles in the onset and pathogenesis of RA by influencing the post-transcriptional expression of key genes involved in synovial inflammation and bone destruction.31,32 Recent studies have highlighted the effect of epigenetic factors, including DNA methyltransferase (DNMT), Lysine-Specific Demethylase 1 (LSD1), and Histone Deacetylase (HDAC), in regulating osteoclastogenesis in RA.33–35 Nevertheless, therapeutic strategies targeting these epigenetic modifications have yet to be validated in RA patients.