To further explore the role of Irg1/ITA in RA, we re-analyzed a single-cell RNA sequencing (scRNA-seq) dataset from Synapse, which included 314 011 cells from 70 RA patients and 9 OA patients.27 Transcriptome analysis revealed that the proportion of IRG1-expressing (IRG1+) myeloid cells was significantly elevated in RA patients compared with OA patients (Fig. S1c, e). This evidence concerns the gene ACOD1 and rheumatoid arthritis.