Tau was reported to damage mitophagy by preventing Parkin translocating to mitochondria.358 In AD model, an increase of Tau and Aβ protein precursor inhibited Parkin translocation to mitochondria, thus Parkin was unable to label impaired mitochondria, and mitophagy was damaged.359 Therefore, enhanced mitophagy is regarded as a strategy to alleviate neurodegeneration360,361 by upregulating PINK1 and Parkin in neurons, thus increasing the activity of microglia to phagocytose Aβ plaques, and improving cognitive and memory function.357. Here, PRKN is linked to Alzheimer disease.