Mitophagy inhibits the excessive inflammatory response induced by mitochondrial damage in autoimmune diseases.422 In SLE, the overexpression of CD38 impairs the PINK-Parkin pathway and disrupts mitophagy, leading to mitochondrial structural defects in SLE patients.423 Stimulating mitophagy has been shown to alleviate lupus nephritis and reduce inflammatory cell infiltration in the kidney.424. The gene discussed is PRKN; the disease is systemic lupus erythematosus.