However, in some liver diseases, giant mitochondria are formed due to increased mitochondrial fusion and decreased fission, which is regarded as the structural marker of liver diseases.412 For example, in alcoholic hepatitis, alcohol inhibits the expression of Drp1 by impairing hepatic transcription factor EB, thus leading to an increase of giant mitochondria in the liver and appearing liver damage.413 Therefore, mitochondrial health is critical to maintaining liver function and preventing disease progression. This evidence concerns the gene DNM1L and liver disorder.