NLRP3 and neoplasm: Metformin effectively decreases the production of ATP and mtDNA, thereby inhibiting NLRP3 inflammasome mitigating acute respiratory distress syndrome and alleviating the resulting lung injury.171 In a tumor environment, tumor immune escape mechanisms will clear eATP to avoid inflammasome and inflammation reaction, therefore, CD39 antibody which inhibits ATP transformation to AMP could enhance ATP-mediated activation of inflammasomes and the corresponding inflammatory response.172