MAPT and neuropathy: DuBoff et al. found mitochondria elongation in Drosophila and mouse neurons.356 Since Tau can bind and stabilize actin, when Tau expression was increased, the over-stabilized actin prevented Drp1 from localization to mitochondria, down-regulated mitochondrial fission, lengthened mitochondrial morphology in neurons, and overproduced ROS, which induced neuropathy.356