Mitochondrial dysfunction in Alzheimer’s disease (AD) includes mitochondrial dynamic changes, a decrease in ATP generation, increased oxidative stress, mitophagy damage and mtDNA mutation.23,346,347 The hallmark changes of AD are an accumulation of amyloid beta (Aβ) protein and phosphorylated Tau (p-Tau) protein.348–351 Their over-accumulation may result in abnormal mitochondrial dynamics and mitophagy.246,352,353. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.