PRKN and Parkinson disease: Earlier studies focusing on post-mortem brains from PD patients verified the decline of OXPHOS, especially complex I activity.364,365 Besides, aberrant mitophagy triggered by PINK and Parkin mutations are associated with PD development in familial PD patients.366 In conclusion, mitochondrial dysfunction is involved in the development of PD by affecting its pathological state, inspiring that the intervention of mitochondrial dysfunction may work as a potential strategy for future PD treatment.