WEE1 and Insulin resistance: Oxidative stress is associated with insulin resistance.369 Advanced glycation end products, which are generated by glucose in a non-enzymatic manner, also promote ROS production and endoplasmic reticulum stress, and then induce insulin suppression via the protein kinase RNA-like endoplasmic reticulum kinase/forkhead box O1 pathway.370 Down-regulation of the mitochondrial fusion protein Mfn2 in the muscle and liver of diabetic patients also induces oxidative stress and leads to insulin resistance.371,372