MFN2 and obesity due to melanocortin 4 receptor deficiency: Mice with high-fat diet showed downregulation of Mfn2 and Opa1 in multiple organs.380 Mfn2 interacts directly with perilipin 1 to promote adrenergic and stimulate interaction between mitochondria and lipid droplets, affecting lipid metabolic processes and thermogenic function in brown adipose tissue.381 Therefore, mitochondrial dynamics is involved in the regulation of obesity by altering lipid metabolism.