Hyperglycemia induces retinal metabolic abnormalities through various pathways, including the polyol pathway, hexosamine pathway, aging, PKC activation, angiotensin II (ANG-II) pathway et al. These abnormal retinal metabolisms further exacerbate damage, leading to the occurrence of DR.433,434 Additionally, hyperglycemia triggers activate oxidative stress and inflammation, along with mitochondrial dysfunction, drawing significant attention from several researchers. The gene discussed is PRRT2; the disease is Hyperglycemia.