Recent studies report that KRAS variants affect the prognosis of patients with colorectal cancer, lung cancer, and BTC.12, 13, 14, 15, 16, 17, 18 However, the detailed association between KRAS variants and OS in BTC patients with different tumor subtypes (IHC, EHC, or GB), as well as their therapeutic outcomes, remains unclear. This evidence concerns the gene KRAS and lung cancer.