HMGB1 and neoplasm: To address this, we have previously developed a silicasome‐based irinotecan delivery platform that not only enhances drug delivery but also induces ICD (Figure S4, Supporting Information).[6, 7, 31, 32] As illustrated in Figure 6A (left panel), irinotecan induces (ICD by exposing CRT as an “eat me” signal while releasing HMGB1 and ATP, which serve as DAMPs that induce the activation and maturation of APC.[3, 6, 25] This process primes CTL against tumor antigens, with the support of the spleen and regional lymph nodes, effectively generating an “endogenous vaccination” response.