To develop an orthotopic KPC tumor model that closely mimics the characteristics of human PDAC, we used KRAS‐transformed murine pancreatic adenocarcinoma cells with stable luciferase expression (KPC‐luc cells), derived from a spontaneous tumor in a transgenic KrasLSL‐G12D/+; Trp53LSL‐R172H/+; Pdx‐1‐Cre mouse model.[6, 7, 8, 9]. This evidence concerns the gene KRAS and pancreatic adenocarcinoma.