In a rat ischemic stroke model, it inhibited the stimulation of microglia and astrocytes and decreased the expression of TNF-α, IL-1β, ıntercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, inducible NO synthase (iNOS), and aquaporin-427. The gene discussed is VCAM1; the disease is ischemic stroke.