ADNP has diverse roles in embryogenesis,111 chromatin reorganization and transcriptional regulation,112,113 and neuronal maturation.114 Mutations in ADNP cause Helsmoortel-Van der Aa syndrome,91 the most common monogenic form of autism (estimated at 0.17% of ASD cases).115 Previous work has linked ADNP to Wnt signalling, with contrasting effects across cellular contexts. This evidence concerns the gene ADNP and ADNP-related multiple congenital anomalies-intellectual disability-autism spectrum disorder.