POU3F2 and Neurodevelopmental delay: One variant (p.Q407R) resides within the POU homeodomain and is predicted to be pathogenic, whereas the other (p.P420T) has mixed pathogenicity predictions and is considered likely benign.106 These findings expand the catalogue of ASD-associated POU3F2 variants and reinforce the role of POU3F2 in conferring risk for neurodevelopmental delay and/or ASD.22,23