ADNP and malignant colon neoplasm: In mouse neurospheres, Adnp loss-of-function decreased β-catenin stabilization and reduced Wnt signalling,94 whereas in human colon cancer cells, ADNP overexpression led to these same effects.93 Here, we show that ADNP overexpression in human NPCs reduces activation of canonical Wnt signalling, suggesting it functions as an inhibitor of Wnt potentiation in this cellular context.