Nonetheless, the MRIdata document once again the increased safety of the tPA-DPN overfree-tPA and the severity of the model that induced lesion volumeslarger than 50 mm3 already within the first 3 h post occlusion.It is here just important to note that other preclinical stroke modelshave typically lesion volumes in the order of 20 to 30 mm3. This evidence concerns the gene PLAT and stroke disorder.