PLAT and Stroke: Nonetheless, the MRIdata document once again the increased safety of the tPA-DPN overfree-tPA and the severity of the model that induced lesion volumeslarger than 50 mm3 already within the first 3 h post occlusion.It is here just important to note that other preclinical stroke modelshave typically lesion volumes in the order of 20 to 30 mm3.