PLAT and Stroke: Their study foundthat tPA-loaded fucoidan microbubbles were 50% more efficient thanfree tPA and required only one-tenth of the standard dose to resolvethe stroke. Moreover, Colasuonno et al.suggested the use of microscopic particlesdiscoidal polymericnanoconstructs (DPN)as vehicles for Alteplase. DPN are made of poly­(lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG), both biocompatibleand clinically approved polymers.