IL5 and Increased total eosinophil count: Although eosinophilia is traditionally linked to the in vivo destruction of Schistosoma eggs in hepatic granulomas (61–63), eosinophil-deficient mouse models (64–67) or mice treated with a monoclonal antibody anti–interleukin-5, an essential cytokine for eosinophil development (68), showed no impact on worm or tissue egg burdens.