Currently established molecules with migraine-triggering abilities include the nitric oxide donor, glyceryl trinitrate, CGRP, PACAP, cilostazol (a phosphodiesterase-3 inhibitor), sildenafil (a phosphodiesterase-5 inhibitor), an adenosine triphosphate-sensitive potassium (KATP) channel opener, and a large conductance calcium-activated potassium (BKCa) channel opener [117]. Here, ADCYAP1 is linked to migraine disorder.