Among the three different tumor areas, we observed a significantly higher frequency of CD4+ T cells expressing IFN‐γ and a slight but not statistically significantly lower expression of IL‐17, in the intermediate tumor area compared with the core and marginal area (Figure 4A,C), whereas no difference was observed for TNF‐α and IL‐10 and (Figure 4 B,D). Here, TNF is linked to neoplasm.