Interestingly, analyzing the different layers we see a not statistically significant trend in a lower expression of IL‐17 in the Intermediate areas while for IL‐10, in particular in CD4+ lymphocytes, there is a statistically significant increase of IL‐10 production in the three tumor layers, compared with PB, with a slight but not statistically significant increment in the Intermediate tumor areas. This evidence concerns the gene CD4 and neoplasm.