Among GBM infiltrating CD8+ T cells, the PD‐1+TIGIT– subpopulation was characterized by the significantly higher frequency of cells expressing IFN‐γ, TNF‐α, and GM‐CSF, followed by the other three subpopulations (Figure 3H–J), while no difference was observed in IL‐17 and IL‐10 production (Figure 3K,L). Here, TNF is linked to glioblastoma.