MAPT and Alzheimer disease: Neuronal survival is reduced in AD due to the induction of neuronal apoptosis, necrosis, ferroptosis, and pyroptosis by Aβ and tau protein, and associated neuroinflammation, oxidative stress, ER stress, and mitochondrial dysfunction (Mangalmurti and Lukens 2022; Shim et al. 2021; Mohamed and Bars 2024).