Consistently, many experimental studies revealed that a dual GIP/GLP-1 receptor agonist DA4-JC has a neuroprotective effect against AD neuropathology by regulating the PI3 K/AKT/GSK3β signaling pathway in AD mouse model (Maskery et al. 2020; Cai et al. 2021). This evidence concerns the gene GLP1R and Alzheimer disease.