While abnormal taste perception can occur during acute episodes of bipolar disorder [102] and changes in the expression of another bitter taste receptor gene TAS2R5, 181 kilobases upstream of TAS2R38, have been observed in manic episodes in patients with bipolar disorder [103], our study provides the first evidence linking TAS2R38 genotype to bipolar disorder. Here, TAS2R5 is linked to bipolar disorder.