In contrast to the previously reported phenotypes of smaller body size, shorter lifespan, and spontaneous T-lymphoma development in Ku70 null mice [27, 29], the Ku70-ΔSAP mice exhibited normal body weight (Supplementary Fig. S3A), unchanged overall survival within the observed ∼600 days of age, and insignificant change of spontaneous tumor incidence (Supplementary Fig. S3B). Here, XRCC6 is linked to neoplasm.