RUNX2 and head and neck squamous cell carcinoma: Previous studies revealed that RUNX2 promotes cancer metastasis and invasion in a variety of cancers, including breast cancer (Chang et al., 2014), thyroid cancer (Sancisi et al., 2012), colorectal cancer (Ji et al., 2019), prostate cancer (Akech et al., 2010), lung cancer (Herreño et al., 2019), and HNSCC (Chang et al., 2016).