TP63, a member of the TP53 family of transcription factors, plays opposite roles in cancer depending on which of its isoforms is expressed within cells: GTA-p63 and TA-p63 have pro-apoptotic and potential anti-tumoral effects, while ∆N-p63 promotes stemness and plays a pro-tumoral function [51,52]. The gene discussed is TP63; the disease is cancer.