MAPT and amyotrophic lateral sclerosis: Remarkably, FTD individuals with a tau pathology presented a significant enrichment of tau protein in neuronal EVs; similarly, FTD (and ALS) patients with TDP-43 pathology had increased TDP-43 levels in neuronal EVs, suggesting the use of neuronal EVs to predict specifically tau or TDP-43 pathology associated with FTD subtypes [99].