TARDBP and frontotemporal dementia: Haploinsufficiency, often resulting from heterozygous GRN mutations, leads to GRN-associated frontotemporal dementia (GRN-FTD), which accounts for 10–15% of all FTD cases and is characterized by lipofuscinosis, microgliosis, TDP-43 pathology, and cortical neuronal loss [92].