As shown in Figure 1A–C, both the Western blots and RT-qPCRs analyses on frozen tissues from a cohort of AD and non-AD control (NC) cases (Tables S1 and S2) revealed more than a 2-fold increase in the steady-state levels of the TRPC3 protein and the Trpc3 mRNA and reduced the TRPC6 protein but did not significantly alter the Trpc6 mRNA in AD samples. The gene discussed is TRPC3; the disease is Alzheimer disease.