The activation of TRPC3 and TRPC6 induced by the angiotensin II-mediated PLC pathway leads to an influx of Ca2+ ions into the myocardial cells, which in turn activates the Ca2+-dependent CaN to dephosphorylate the NFAT, allowing it to translocate to the nucleus and activate the transcription of genes involved in cardiac hypertrophy, including TRPC3 and TRPC6. Here, HSPG2 is linked to cardiac hypertrophy.