TRPC6 and cardiac hypertrophy: The activation of TRPC3 and TRPC6 induced by the angiotensin II-mediated PLC pathway leads to an influx of Ca2+ ions into the myocardial cells, which in turn activates the Ca2+-dependent CaN to dephosphorylate the NFAT, allowing it to translocate to the nucleus and activate the transcription of genes involved in cardiac hypertrophy, including TRPC3 and TRPC6.