TRPC3 and cardiac hypertrophy: We then searched for the reported mechanisms for the upregulated Trpc3 gene under pathological conditions and found that both the TRPC3 and TRPC6 genes were reportedly upregulated under cardiac hypertrophy, a condition where the heart muscle thickens and stiffens the heart tissue [49] by the Ca2+/calmodulin-dependent phosphatase 2B (calcineurin/CaN) coupled nuclear factor of the activated T cells (NFAT) pathway.