Indeed, the TRPC3 DAB immunosignals revealed significantly higher expressional levels of the TRPC3 protein in AD brain prefrontal cortical (PFC) specimens from a different cohort of patients compared to the non-AD controls (NCs) (Table S3, Figure 1D), most notably in those large pyramidal neurons (Figure 1E, red arrowheads). The gene discussed is TRPC3; the disease is Alzheimer disease.