To address the further maturation of neural progenitor cells during experimental ileocolitis, we characterized DCX+ neuroblasts in the DG and found no significant changes in absolute numbers of DCX+ cells between Casp8ΔIEC mice and Casp8fl controls (Casp8fl vs. Casp8ΔIEC 14 weeks: 10,660 ± 4516 vs. 10,538 ± 3112, p > 0.999; 24 weeks: 8328 ± 4380 vs. 8013 ± 7236, p = 0.957; Figure 3D). Here, DCX is linked to ileocolitis.