The detected minimal decrease in NeuN expression in DCX+ neuroblasts in 24-week-old Casp8ΔIEC mice compared to Casp8fl controls can mainly be attributed to an unexpected slight increase in proportional NeuN-positivity in Casp8fl mice between 14 and 24 weeks of age but is very unlikely to reflect a biologically relevant impairment in neuroblast maturation due to ileocolitis, especially as all other neurogenesis-related parameters are preserved. Here, DCX is linked to ileocolitis.