Numerous prospective studies on PAH have revealed enhanced regulation of adhesion molecules, including soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK), P-selectin, vascular cell adhesion molecule-1 (VCAM-1), and platelet-derived microparticles (PMPs), which facilitate platelet adhesion and activation, strongly correlated with RV dysfunction and disease progression [123,124,125,126]. This evidence concerns the gene VCAM1 and pulmonary arterial hypertension.