ADIPOQ and obesity due to melanocortin 4 receptor deficiency: For further characterization, we analyzed the expression of three marker genes for obesity, the pro-inflammatory cytokine Il6 [36,37,38] and the adipokines Lep [39,40,41] and AdipoQ [42,43], using RNAseq datasets of visceral AT and visceral adipocytes from lean and obese mice [32].