TYMS and colorectal carcinoma: Similar to the findings in the present study, the chemosensitizing activity of Gan has been published for several CRC cell lines, and various mechanisms of action have been identified: destabilization of the Hsp90 interaction with several client proteins resulted in the downregulation of the thymidylate synthase, which is the target of 5-FU, as well as the inhibition of various proliferation signaling pathways [62,63].