Based on post-mortem studies, a-synuclein inclusions in the brain of patients suffering from some synucleinopathies, particularly idiopathic PD and LBD, are expected to be found in a much lower density compared to other protein aggregates, such as amyloid and tau, for which PET tracers have been successfully developed [11]. The gene discussed is SNCA; the disease is synucleinopathy.