SNCA and multiple system atrophy: Under pathological conditions, a-synuclein can progressively misfold and aggregate, forming intracellular neuronal deposits known as Lewy bodies and Lewy neurites, which represent the neuropathological hallmark of Parkinson’s disease (PD) and Lewy body dementia (LBD) or glial cytosolic inclusions (GCIs) in MSA [2].