CASP3 and Alzheimer disease: Analysis of hippocampal protein lysates from both vehicle AD mouse models revealed a substantial ~70–80% increase in cleaved caspase-3 (Clv.C-3) levels, indicating heightened neurodegeneration during disease progression (5xFAD vehicle: p < 0.001; Tg2576 vehicle: p < 0.01, vs. WT).