5-aza-2′-deoxycytidine (5-Aza) induced melanoma cell apoptosis by upregulating tumor necrosis factor (TNF)-α, Fas ligand (FasL), and TNF-related apoptosis-inducing ligand (TRAIL), demonstrating anti-melanoma effects with minimal impact on normal human melanocytes in vitro [31]. The gene discussed is TNFSF10; the disease is melanoma.