Salicylazosulfapyridine (SSZ), a common anti-inflammatory drug, induces ferroptosis in melanoma cells by upregulating the expression of prostaglandin endoperoxide synthase 2 (PTGS2) and acyl-CoA synthase long-chain family member 4 (ACSL4), inhibiting the synthesis of GPX4 and FTH1, and promoting intracellular lipid peroxidation [126]. Here, PTGS2 is linked to melanoma.