GZMA and neoplasm: In the granzyme-mediated pathway, granzymes, including granzyme A (GZMA) and granzyme B (GZMB), derived from natural killer cells or cytotoxic T lymphocytes, enter target cells via perforin, cleaving specific members of gasdermin family including GSDMB and GSDME to induce pyroptosis in cancer cells, thereby enhancing the inflammatory response within the tumor microenvironment and promoting antitumor immunity [69].