Jazirehi et al. confirmed that histone deacetylase inhibitors (HDACi) not only up-regulated the expression of TRAIL and DR5 to activate the TRAIL/DR5 apoptotic signaling pathway but may also promote the recognition and killing of melanoma cells by cytotoxic T lymphocytes (CTL), further enhancing apoptosis in vitro [27]. This evidence concerns the gene TNFRSF10B and melanoma.