CASP3 and melanoma: Wang et al. confirmed that hernandezine, a bisbenzylisoquinoline alkaloid extracted from the traditional Chinese herbal medicine Thalictrum glandulosissimum, up-regulated Bax but down-regulated Bcl-2, thereby increasing the activation and cleavage of apoptosis-related proteins such as Caspase-3 and Caspase-9, ultimately inducing apoptosis in melanoma cells such as A375 and B16 in vitro [34].