EP300 and benign neoplasm: Moreover, TGF-β fails to promote myofibroblast differentiation in the absence of p300, underlining the importance of this protein as a profibrogenic epigenetic regulator, likely through its recruitment to the collagen gene promoter and interaction with the TGF-β-activated Smad2/3/Smad4-Sp1 complex [84], highlighting the importance of p300 in the context of developing heart pathologies.