Although the predominant ubiquitin chain topology (e.g., K48 vs. K63 linkages) involved in USP14-mediated Survivin stabilization remains to be fully elucidated, USP14 has been discovered to be highly expressed across various cancer types and plays a critical role in regulating protein stability and degradation within several important signaling pathways, including Survivin in other cancers [25,26]. The gene discussed is USP14; the disease is cancer.