FGF21 and diabetes mellitus: On the other hand, rBMAds boosters include a high-fat diet [148,152], caloric restriction (CR) [153,154,155], treatments with thiazolidinediones and glucocorticoids [156,157], fibroblast growth factor 21 (FGF21) [158], insulin-dependent diabetes mellitus (type I diabetes) [159], irradiation [91], and aging [90,160].