CASP4 and amyloidosis: To investigate the role of caspase-4 in the development of amyloid-related pathologies induced by P. gingivalis-LPS, we used SH-SY5Y cells due to the absence of detectable release of Aβ1–42 and Aβ1–40 peptides in P. gingivalis-LPS-transfected HMC3 microglial cells [31].