Moreover, elevated IL-1β levels observed in various GBM cell lines, including CCF3 and U-87 [69], U373MG [70] and in human GBM tumor samples [71] were associated with the activation of the NF-κB and mitogen-activated protein (MAPK) signaling cascades, enhancing tumor cell invasiveness. The gene discussed is IL1B; the disease is glioblastoma.