Additionally, since Fh12, a native fatty acid binding protein of F. hepatica, has been proposed as a TLR4 antagonist [64] and we have demonstrated that Fh12 and Fh15 share immunologic and antigenic properties [65], we could speculate that Fh15 could also suppress the overexpression of TLR4, which is directly associated with the severity and progression of DSS-induced colitis [66,67]. This evidence concerns the gene TLR4 and colitis.