Studies have shown that the activity of the AMPK-ULK1-FUNDC1 signaling pathway is significantly inhibited in the neurotrophic tyrosine kinase receptor 1 (NTRK1) knockout mouse model and that this inhibition blocks mitophagy and leads to dysfunctional mitochondria, enhanced oxidative stress, and synaptic damage in hippocampal neurons, ultimately leading to cognitive deficits [69]. Here, NTRK1 is linked to Cognitive impairment.