In this study, among the DP-detrimental genes, Jun was enriched in ‘pathways in cancer’, ‘focal adhesion’, ‘fluid shear stress and atherosclerosis’ and ‘AGE-RAGE SP in diabetic complications’, and Fos was enriched in ‘pathways in cancer’ and ‘fluid shear stress and atherosclerosis’ pathways. The gene discussed is FOS; the disease is atherosclerosis.