SLFN11 and leukemia: To further examine whether SLFN11 can directly impact LINE-1 elements on chromatin, we re-analyzed the available ATAC-seq (Assay for Transposase-Accessible Chromatin with high throughput sequencing) data [32] obtained from human leukemia CCRF-CEM SLFN11-positive cells and the corresponding SLFN11-KO cells.